News

  • Kelley group research recognized with ACS Nanoscience Award

    Wed, 17 May 2017

    Our work on biointerfaced nanomaterials was recently recognized with the ACS Inorganic Nanoscience Award.

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  • Publication in Nature Nanotechnology showcases our new rare cell profiling technology

    Publication in Nature Nanotechnology showcases our new rare cell profiling technology

    Mon, 21 Nov 2016

    Magnetic ranking cytometry: a new method for rare cell characterization

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  • Nature paper demonstrates record-breaking carbon dioxide reduction efficiency with gold NMEs

    Nature paper demonstrates record-breaking carbon dioxide reduction efficiency with gold NMEs

    Mon, 15 Aug 2016

    In a Nature paper published this month, the gold nanostructured microelectrodes (NMEs) developed in our group were shown to promote high levels of carbon dioxide reduction.  These structures, composed of sharp gold nanoneedles, were originally developed for use as ultrasensitive biomolecular detectors (Nature Nano 2009, Nature Chemistry 2012, Nature Chemistry 2015).  In the recent Nature paper showcasing a collaboration with the Sargent group, the sharp tips of the needles were shown to promote local high electric fields that concentrate electrolyte cations that facilitate CO2 reduction.  This work was featured by Forbes....

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  • Our high-throughput screen for novel mitochondrial proteins published in Nature Chemical Biology

    Our high-throughput screen for novel mitochondrial proteins published in Nature Chemical Biology

    Mon, 06 Jun 2016

    A study led by Biochemistry Ph.D. student Simon Wisnovsky leveraged mitochondria-specific chemical probes developed in the Kelley group to screen for new proteins with mitochondrial function.  By looking at the synergistic activity of chemical probes and siRNAs that knocked down known nuclear repair factors, a variety of hits were identified.  The set of proteins that were found in the screen were confirmed to exhibit mitochondrial localization, and several, including a DNA polymerase that had never been connected with mitohcondria previously, were shown to be essential for efficient mitochondrial function.  The paper appeared in Nature Chemical Biology. ...

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  • A multi-dimensional approach for cell sorting and characterization described in J. Am. Chem. Soc.

    A multi-dimensional approach for cell sorting and characterization described in J. Am. Chem. Soc.

    Wed, 02 Mar 2016

    Cancer cells, and in particular those found circulating in blood, can have widely varying phenotypes and molecular profiles despite a common origin.  New methods are needed that can deconvolute the heterogeneity of cancer cells and sort small numbers of cells to aid in the characterization of cancer cell subpopulations. In the March 2nd issue of the Journal of the American Chemical Society, we described a new molecular approach to capturing cancer cells that isolates subpopulations using two-dimensional sorting. Using aptamer-mediated capture and antisense-triggered release, the new strategy sorts cells according to levels of two different markers and thereby separates them into their corresponding subpopulations. Using a phenotypic assay, we demonstrate that the subpopulations isolated have markedly different properties. This system provides an important new tool for identifying CTC subtypes exhibiting the greatest clinical relevance....

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  • Kelley group research recognized with Brockhouse Canada Prize

    Kelley group research recognized with Brockhouse Canada Prize

    Thu, 18 Feb 2016

    The Brockhouse Canada Prize for Interdisciplinary Research in Science and Engineering recognizes outstanding Canadian teams of researchers from different disciplines who have combined their expertise to produce achievements of outstanding international significance in the natural sciences and engineering.  The work of the Kelley group on the development of new nanomaterials for biological sensing, carried out in collaboration with the Sargent group, was recognized with this exciting award....

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  • Technologies developed by the Kelley group recognized with the 2016 SLAS Innovation Award

    Technologies developed by the Kelley group recognized with the 2016 SLAS Innovation Award

    Wed, 27 Jan 2016

    Technologies developed by the Kelley group recognized with the 2016 SLAS Innovation Award

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  • Article on Kelley group sensing work published in Scientific American

    Tue, 20 Oct 2015

    Article on Kelley group sensing work published in Scientific American

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  • Chip for transplant markers appears in Science Advances, featured in C&E News, Scientific American

    Fri, 28 Aug 2015

    Rapid assay for lung transplant markers published in Science Advances, featured in C&E News and GenomeWeb

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  • Chip-based analysis of circulating nucleic acids in cancer patients published in Nature Chemistry

    Mon, 01 Jun 2015

    Electrochemical analysis of circulating nucleic acids in cancer patients published in Nature Chemistry

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  • New tumour cell sorting device reported in Angewandte Chemie, featured in Science

    Wed, 05 Nov 2014

    New work in the Kelley group was published today detailing a device that not only captures circulating tumor cells in blood, but also sorts them into discrete subpopulations depending on levels of surface markers.

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  • Kelley laboratory featured on BBC Radio

    Sat, 20 Sep 2014

    The BBC Radio program The Forum recorded a session on the Challenges of Nanoscience and featured the work of the Kelley Lab on bimolecular detection using nanomaterials.

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  • Kelley lab receives $6M in funding for work on low-cost infectious disease testing

    Tue, 01 Apr 2014

    Genome Canada, the Ontario Ministry of Research and Innovation, and Xagenic Inc. will support research in the Kelley Labs with $6M in grant funding; a low-cost, instrument free testing solution will be developed for rapid diagnosis of infectious disease.

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  • Kelley group publishes review in ACS Chemical Biology

    Fri, 21 Feb 2014

    A review of the field of mitochondrial drug delivery and probes for mitochondrial chemical biology was published in ACS Chemical Biology (link).  The lead author, Sae Rin Jean, is a second-year Ph.D. student in the Chemistry graduate program....

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  • ACS Nano publishes study of proximal bacterial lysis and detection

    Fri, 09 Aug 2013

    A study led by Biomedical Engineering Ph.D. student Justin Besant focused on a device that can lyse and detect bacterial cells

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  • Solution-based circuit approach published in Nature Communications

    Wed, 12 Jun 2013

    An effort spearheaded by Chemistry Ph.D. student Brian Lam to build a highly multiplexed chip for pathogen detection was published by Nature Communications.

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  • Kelley lab awarded CHRP grant

    Mon, 22 Apr 2013

    The Kelley lab was awarded a Collaborative Health Research Project (CHRP) grant from NSERC and CIHR for a project that will develop a rapid method for the profiling of lung transplant markers that can predict patient outcomes.  The project is a collaboration with the Sargent group in Electrical Engineering, and the Liu and Keshavjee groups at the Latner Thoracic Research Laboratories....

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  • Queen Elizabeth II Diamond Jubilee Medal Awarded

    Sat, 20 Apr 2013

    Shana Kelley has been awarded a Queen Elizabeth II Diamond Jubilee Medal....

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  • Kelley Lab study of mitochondrially-targeted doxorubicin published in ACS Chemical Biology

    Tue, 16 Apr 2013

    Doxorubicin, a commonly-used anticancer agent, typically causes damage within cells via its ability to disrupt the function of nuclear topoisomerase.  Targeting this drug to the mitochondria instead allows the drug to maintain activity, but with toxicity that is not affected by the presence of efflux pumps.  This study was recently published in ACS Chemical Biology and a podcast was also recorded describing this work....

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