Google Scholar Publication Listing

  1. “Tracking the Dynamics of Circulating Tumor Cell Phenotypes Using Nanoparticle-Mediated Magnetic Ranking.”
     M. Poudineh, P.M. Aldridge, S. Ahmed, B.J. Green, L. Kermanshah, V. Nguyen, C. Tu, R.M. Mohamadi, R.K. Nam, A. Hansen, S.S. Sridhar, A. Finelli, N.E. Fleshner, A.M. Joshua, E.H. Sargent,  S.O. Kelley 
    Nature Nanotechnology, 2017, 12, 274-282. link

  2. "Power-Free, Digital and Programmable Dispensing of Picoliter Droplets using a Digit Chip"
     A. Mepham, J. Besant, A. Weinstein, I. Burgess, E.H. Sargent, S.O. Kelley
     Lab On A Chip, 2017, in press, doi: 10.1039/C7LC00199A. link

  3. "High-Curvature Nanostructuring Enhances Probe Display for Biomolecular Detection."
     P. De Luna, S.S. Mahshid, J. Das, B. Luan, E.H. Sargent, S.O. Kelley, R. Zhou
     Nano Letters, 2017, 17, 1289-1295. link

  4. "Chemistry-Driven Approaches to Ultrasensitive Nucleic Acid Detection."
     S.J. Smith, C.R. Nemr, S.O. Kelley
     Journal of the American Chemical Society2017, 139, 1020-1028. link

  5. "Advancing Ultrasensitive Molecular and Cellular Analysis Methods to Speed and Simplify the Diagnosis of Disease."
     S.O. Kelley
    Accounts of Chemical Research, 2017, 50, 503-507 ("Holy Grails in Chemistry" issue). link

  6. "Profiling Functional and Biochemical Phenotypes of Circulating Tumor Cells Using a Two-Dimensional Sorting Device."
     M. Poudineh, M. Labib, S. Ahmed, L.N.M. Nguyen, L. Kermanshah, R.M. Mohamadi, E.H. Sargent, S.O. Kelley
     Angew. Chem. Intl. Ed., 2017, 56, 163-168. link

  7. "What are Clinically-Relevant Levels of Cellular and Biomolecular Analytes?"
     S.O. Kelley
     ACS Sensors2017, 2, 193-197. link

  8. "Enhanced Electrocatalytic Carbon Dioxide Reduction via Field-Inducted Reagent Concentration."
     M. Liu, Y. Pang, B. Zhang, P. De Luna, O. Voznyy, J. Xu, X. Zheng, C. T. Dinh, F. Fan, C. Cao, F. P. García de Arquer, T. S. Safaei, A. Mepham, A. Klinkova, E. Kumacheva, T. Filleter, D. Sinton,  S.O. Kelley and E.  H. Sargent  
     Nature
    , 2016, 537, 382-386. link

  9. "DNA Clutch Probes for Circulating Tumor DNA Analysis."
     J. Das, I. Ivanov, E.H. Sargent, S.O. Kelley 
     Journal of the American Chemical Society, 2016138, 11009-11016. link

  10. "Mechanistic Control of the Growth of Three-Dimensional Gold Sensors."
     S. Mahshid, A.H. Mepham, S.S. Mahshid, I.B. Burgess, T.S.Safaei, E.H. Sargent, S.O. Kelley 
     Journal of Physical Chemistry C2016, 120, 21123-21132. link

  11. “High-Density Nanosharp Microstructures Enable Efficient Carbon Dioxide Electroreduction.”
     T.S. Safaei, A. Mepham, X. Zheng, Y. Pang, C.-T. Dinh, D. Sinton, S.O. Kelley, E.H. Sargent, 
     Nano Letters, 2016, 11, 7224-7228. link

  12. "Mitochondria-Targeted Doxorubicin: a New Therapeutic Strategy Against Doxorubicin-Resistant Osteosarcoma."  
     I. Buondonno, E. Gazzano, S.R. Jean, V. Audrito, J. Kopecka, M. Fanelli, I. C. Salaroglio, C. Costamagna, I. Roato, E. Mungo, C. M. Hattinger, S. Deaglio, S.O. Kelley, M. Serra, C. Riganti, 
     Molecular Cancer Therapeutics2016, 15, 2640-2652. link

  13. "Mitochondrial DNA Repair and Replication Proteins Revealed by Targeted Chemical Probes."
     S. Wisnovsky, S.R. Jean, S.O. Kelley
     Nature Chemical Biology2016, 12, 567-573. link

  14. "Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell."
     S. Wisnovsky, E.K. Lei, S.R. Jean, S.O. Kelley 
     Cell Chemical Biology2016, 23, 917-927. link

  15. "Aptamer and Antisense-Mediated Two-Dimensional Isolation of Specific Cancer Cell Subpopulations."
     M. Labib, B. Green, R. Mohamadi, A. Mepham, S. Ahmed, L. Mahmoudian, I.-H. Chang, E.H. Sargent, S.O. Kelley
     Journal of the American Chemical Society2016, 138, 2476-2479. link

  16. "Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria."
     S.R. Jean, M. Ahmed, E.K. Lai, S.P. Wisnovsky
     Accounts of Chemical Research201649, 1893-1902. link

  17. "Electrochemical Methods for the Analysis of Clinically-Relevant Biomolecules."
     M. Labib, E.H. Sargent, S.O. Kelley
     Chemical Reviews2016, 116, 9001-9090. link

  18. "Image-Reversal Soft Lithography: Fabrication of Ultrasensitive Biomolecular Detectors."
     T.S.S. Safaei, J. Das, S.S. Mahshid, P.M. Aldridge, E.H. Sargent, S.O. Kelley 
     Advanced Healthcare Materials2016, 5, 893-899. link

  19. “Beyond CTC Capture: Next-Generation Devices and Materials.”
     B. Green, T. Saberi Safaei, A. Mepham, M. Labib, R.M. Mohamadi, S.O. Kelley 
     Angew. Chem. Intl. Ed., 2016, 55, 1252-1265. link

  20. "Interrogating Circulating Microsomes and Exosomes Using Metal Nanoparticles."
     Y.-G. Zhou, R.M. Mohamadi, M. Poudineh, L. Kermanshah, S. Ahmed, T.S. Safaei, J. Stojcic, R.K. Nam, E.H. Sargent, S.O. Kelley 
     Small2016, 12, 727-732. link

  21. "Peptide Targeting of an Antibiotic Prodrug Towards Phagosome-Entrapped Mycobacteria."
     M.P. Pereira, J. Shi, S.O. Kelley 
     ACS Infectious Disease20151, 586-592. link

  22. "Mitochondrial Targeting of Doxorubicin Eliminates Nuclear Effects Associated with Cardiotoxicity."
     S.R. Jean, D.V. Tulumello, C. Riganti, S.U. Liyanage, A.D. Schimmer, S.O. Kelley
     ACS Chemical Biology, 201510, 2007-2015. link

  23. “An Electrochemical Clamp Assay for Direct, Rapid Analysis of Circulating Nucleic Acids in Serum.”
     J. Das, I. Ivanov, E.H. Sargent, S.O. Kelley 
     Nature Chemistry20157, 569-575. link 

  24. "Disease Detectors."
     S.O. Kelley
     Scientific American, 2015, 313, 49-51. link

  25. “Fractal Circuit Sensors Enable Rapid Quantification of Biomarkers for Donor Lung Assessment for Transplantation.”
     A.T. Sage, J.D. Besant, L. Mahmoudian, M. Poudineh, X. Bai, R. Zamel, M. Hsin, E.H. Sargent, M. Cypel, M. Liu, S. Keshavjee, S.O. Kelley
     Science Advances, 2015, 1, e1500417link (featured in C&E News)

  26. "A Digital Microfluidic Device with Integrated Nanostructured Microelectrodes for Electrochemical Immunoassays."
     D.G. Rackus, M.D.M. Dryden, A. Zaragoza, J. Lamanna, B. Lam, S.O. Kelley, A.R. Wheeler 
     Lab on a Chip201515, 3776-3784. link

  27. "Using the Inherent Chemistry of the Endothelin-1 Peptide to Develop a Rapid Assay for Pre-transplant Donor Lung Assessment."
     A.T. Sage, X. Bai, M. Cypel, M. Liu, S. Keshavjee, S.O. Kelley
     Analyst2015140, 8092-8096. link

  28. “Sorting of Circulating Tumor Cells by Epithelial Antigen Expression during Disease Progression in an Animal Model.”
     N. Muhanna, A. Mepham, R. Mohamadi, H. Chan, T. Khan, M. Akens, J.D. Besant, J. Irish, S.O. Kelley
     Nanomedicine: Nanotechnology, Biology, and Medicine2015, 11, 1613-1616. link

  29. "In Situ Electrochemical ELISA for Specific Identification of Captured Cancer Cells."
     T. Saberi Safaei, R.M. Mohamadi, E.H. Sargent, S.O. Kelley 
     ACS Appl. Mater. Interfaces2015, 7, 14165-14169. *Selected as an ACS Editors Choice Article link

  30. "Sample-to-Answer Isolation and mRNA Profiling of Circulating Tumor Cells."
     R. M. Mohamadi, I. Ivanov, J. Stojcic, R.K. Nam, E.H. Sargent, S.O. Kelley 
     Analytical Chemistry, 2015, 87, 6258–6264link

  31. "Rapid Electrochemical Phenotypic Profiling of Antibiotic-Resistant Bacteria."  
     J.D. Besant, E.H. Sargent, S.O. Kelley 
     Lab on a Chip201515, 2799-2807. link

  32. “Programmable Definition of Nanogap Electronic Devices with Self-Inhibited Reagent Depletion.”
     B. Lam, W. Zhou, E.H. Sargent, S.O. Kelley 
     Nature Communications, 2015, 6, 6940. link

  33. “Ultrasensitive Visual Readout of Nucleic Acids using Electrocatalytic Fluid Displacement.”
     J.D. Besant, J. Das, I.B. Burgess, W. Liu, E.H. Sargent, S.O. Kelley 
     Nature Communications, 2015, 6, 6978. link

  34. “Velocity Valleys Enable Efficient Capture and Spatial Sorting of Nanoparticle-Bound Cancer Cells.”
     J.D. Besant, R.M. Mohamadi, P. Aldridge, Y.Li, E.H. Sargent, S.O. Kelley 
     Nanoscale, 2015, 7, 6278-6285. link

  35. "Nanoparticle-Mediated Binning and Profiling of Heterogeneous Circulating Tumor Cell Subpopulations." 
     R.M. Mohamadi, I. Ivanov, J.D. Besant, A. Malvea, A. Mepham,  J. Stojcic, A.L. Allan, L.E. Lowes, R.K. Nam, E.H. Sargent, S.O. Kelley 
     Angew. Chem. Intl. Ed., 2015, 127, 141-145. link  (featured in Science, “Editor’s Choice”).

  36. “Advancing the Speed, Sensitivity and Accuracy of Biomolecular Detection with Multi-Length Scale Engineering.”
     
    S.O. Kelley, C.A. Mirkin, D.R. Walt, R.F. Ismagilov, M. Toner, E.H. Sargent, 
     Nature Nanotechnology, 2014, 9, 969-980. link

  37. "Highly Specific Electrochemical Analysis of Cancer Cells using Multi-Nanoparticle Labeling."
     Y. Wan*, Y. Zhou*, M. Poudineh, T. Saberi Safaei, R.M. Mohamadi, E.H. Sargent, S.O. Kelley 
    Angew. Chem. Intl. Ed.2014, 53, 13361-13365. link

  38. "Effect of Microelectrode Structure on Electrocatalysis at Nucleic Acid-Modified Sensors."
     Y. Zhou, Y. Wan, A. Sage, M. Poudineh, S.O. Kelley
     Langmuir2014, 30, 14322-14328. link

  39. "Structural Modifications of Mitochondria-Targeted Chlorambucil Alter Cell Death Mechanism but Preserve MDR Evasion."
     S.R. Jean, M.P. Pereira, S.O. Kelley 
    ACS. Mol. Pharm.20148, 2675-2682. link

  40. "Ultrasensitive Electrochemical Biomolecular Detection using Nanostructured Microelectrodes."
     A.T. Sage, J.D. Besant, B. Lam, E.H. Sargent, S.O. Kelley, 
     Acc. Chem. Res.201447, 2417-2425. link

  41. “Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s.”
     G. Giulio, E.-K. Bang, G. Molinard, D. Tulumello, S. Ward, S.O. Kelley, A. Roux, N. Sakai, S. Matile
     J. Am. Chem. Soc., 2014, 136, 6069-6074. link

  42. "Three-Dimensional, Sharp-Tipped Electrodes Concentrate Applied Fields to Enable Direct Electrical Release of Intact Biomarkers from Cells." 
     M. Poudineh, R. Mohamedi, A. Sage, L. Mahmoudian, E.H. Sargent, S.O. Kelley
     Lab on a Chip, 2014, 14, 1785-1790. link

  43. "Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery."
     S.R. Jean, D.V. Tulumello, S.P. Wisnovsky, E.K. Lei, M.P. Pereira
     ACS Chem. Biol., 20149, 323-333. link

  44. "Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent."
     S.P. Wisnovsky, J.J. Wilson, R. J. Radford, M.P. Pereira, M. Chan, R. Laposa, S.J. Lippard, S.O. Kelley 
    Chem. Biol., 2013, 20, 1323-1328. link

  45. "Proximal Bacterial Lysis and Detection in Nanoliter Wells Using Electrochemistry."
     J.D. Besant, J. Das, E.H. Sargent, S.O. Kelley 
     ACS Nano, 2013, 7, 8183-8189. link

  46. "Tuning the Intracellular Bacterial Targeting of Peptidic Vectors."
     E. Lei, M. P. Pereira, S.O. Kelley,
     Angew. Chem. Intl. Ed., 2013, 52, 9660-9663. link

  47. "Solution-Based Circuits Enable Rapid and Multiplexed Pathogen Detection."
     B. Lam, R.D. Holmes, L. Live, A. Sage, E. H. Sargent, S.O. Kelley
     Nature Comm.2013, 4, 2001. link

  48. "Tuning the Bacterial Detection Sensitivity of Nanostructured Microelectrodes."
     J. Das, S.O. Kelley 
     Anal. Chem., 2013, 85, 7333-7338. link

  49. "Targeted Delivery of Doxorubicin to Mitochondria." G. Chamberlain, D.V Tulumello, S.O. Kelley 
     ACS Chem. Biol., 2013, 8, 1389-1395. link

  50. "An Electrochemical ELISA Featuring Proximal Reagent Generation: Detection of HIV Antibodies in Clinical Samples."
     A. Bhimji, A. Zaragoza, L. Live, S.O. Kelley
     Anal. Chem.2013, 85, 6813-6819. link

  51. "Optimized Templates for Bottom-Up Growth of High-Performance Integrated Biomolecular Detectors." 
     B. Lam, R.D. Holmes, J. Das, M. Poudineh, A. Sage, E.H. Sargent, S.O. Kelley
     Lab on a Chip, 2013, 13, 2569-2575. link

  52. "Re-directing an Alkylating Agent to Mitochondria Alters Drug Target and Cell Death Mechanism." 
     R. Mourtada, S. B. Fonseca, S.P. Wisnovsky, M.P. Pereira, X. Wang, R. Hurren, J. Parfitt, L. Larsen, R.A.J. Smith, M.P. Murphy, A.D. Schimmer, S.O. Kelley 
     PLOS One, 2013, 8, e60253. link

  53. "Rapid and Specific Electrochemical Detection of Prostate Cancer Cells Using an Aperture Sensor Array." 
     M. Moscovici, A. Bhimji, S.O. Kelley 
     Lab on a Chip, 2013, 13, 940-946. link

  54. "Chip-Based Nanostructured Sensors Enable Accurate Identification and Classification of Circulating Tumor Cells in Prostate Cancer Patient Blood Samples ." 
     I. Ivanov, J. Stojcic, A. Stanimirovic, E. Sargent, R.K. Nam, S.O. Kelley 
     Anal. Chem., 2013, 85, 398-403. link

  55. "DNA-Based Programming of Quantum Dot Properties." 
     K.B. Cederquist, S.O. Kelley 
     WIREs: Nanomedicine and Nanobiotechnology, 2013, 5, 86-96. link

  56. "An Ultrasensitve, Universal Detector Based on Neutralizer Displacement." 
     J. Das, K.B. Cederquist, P. Lee, E.H. Sargent, S.O. Kelley 
     Nature Chemistry, 2012, 4, 642-648. link

  57. "Polymerase Chain Reaction-Free, Sample-to-Answer Bacterial Detection in 30 Minutes with Integrated Cell Lysis." 
     B. Lam, Z. Fang, E.H. Sargent, S.O. Kelley 
     Anal. Chem., 2012, 84, 21-25. link

  58. "Tuning the Activity of Mitochondria-Penetrating Peptides for Delivery or Disruption." 
     K.L. Horton, M.P. Pereira, K.M. Stewart, S.B. Fonseca, S.O. Kelley 
     ChemBioChem, 2012, 13, 476-485. link

  59. "Nanostructured Biomolecular Detectors: Pushing Performance at the Nanoscale." 
     K.B. Cederquist, S.O. Kelley 
     Curr. Opin. Chem. Biol., 2012, 16, 415. link

  60. "DNA-Based Programming of Quantum Dot Valency, Self-Assembly, and Luminescence" 
     G. Tikhomirov, S. Hoogland, P.E. Lee, A. Fischer, E.H. Sargent, S.O. Kelley 
     Nature Nanotechnology, 2011, 6, 485. link

  61. "Direct Genetic Analysis of Ten Cancer Cells: Tuning Molecular Probe Design for Efficient mRNA Capture" 
     E. Vasilyeva, Z. Fang, M. Minden, E.H. Sargent, S.O. Kelley 
     Angew. Chem. Intl. Ed., 2011, 50, 4137. link

  62. "Maximizing the Therapeutic Window of an Antimicrobial Drug by Imparting Mitochondrial Sequestration in Human Cells " 
     M.P. Pereira, S.O. Kelley 
     J. Am. Chem. Soc., 2011, 133, 3260. link

  63. "Hierarchical Nanotextured Microelectrodes Overcome the Molecular Transport Barrier to Achieve Rapid, Direct Bacterial Detection" 
     L. Soleymani, Z. Fang, B. Lam, X. Bin, E. Vasilyeva, A. Ross, E.H. Sargent, S.O. Kelley
     ACS Nano, 2011, 5, 3360. link

  64. "Development of Novel Peptides for Mitochondrial Drug Delivery: Amino Acids Featuring Delocalized Lipophilic Cations" 
     K.M. Stewart, R. Mourtada, S.O. Kelley 
     Pharm. Res., 2011, 28, 2808. link

  65. "Peptide-Chlorambucil Conjugates Combat Pgp-Dependent Drug Efflux" 
     S.B. Fonseca, S.O. Kelley 
     ACS Med. Chem. Lett., 2011, 2, 419. link

  66. "Re-routing Chlorambucil to Mitochondria Enhances Potency and Combats Drug Resistance in Cancer Cells" 
     S.B. Fonseca, M.P. Pereira, R. Mourtada, M. Gronda, R. Hurren, M.D. Minden, A.D. Schimmer, S.O. Kelley 
     Chem. Biol., 2011, 18, 445. link

  67. "Solvatochromic Reagents for Multicomponent Reactions and their Utility in the Development of Cell-Permeable Macrocyclic Peptide Vectors" 
     B.H.Rotstein, R. Mourtada, S.O. Kelley, A.K. Yudin 
     Chemistry, 2011, 17, 12257. link

  68. "Protein Detection Using Arrayed Microsensor Chips: Tuning Sensor Footprint to Achieve Ultrasensitive Readout of CA-125 in Serum and Whole Blood."  
     J.Das, S.O. Kelley
     Analytical Chemistry, 2011, 83, 1167.

  69. “Nanostructuring of Sensors Determines the Hybridization of Biomolecular Capture.”
     X. Bin, E.H. Sargent, S.O. Kelley
     Analytical Chemistry, 2010, 82, 5928.

  70. "Nucleic Acid-Passivated Nanocrystals: Biomolecular Templating of Form and Function."  
     N. Ma, G. Tikhomirov, S.O. Kelley
    Accounts of Chemical Research, 2010, 43, 173.

  71. "The Antiparasitic Agent Ivermectin Induces Chloride-Dependent Membrane Hyperpolarization and Cell Death in Leukemia Cells."  
     S. Sharmeen, M. Skrtic, M.A Sukhai, R. Hurren, M. Gronda, X. Wang, S.B. Fonseca, H. Sun, M.D. Minden. R. Batey, A. Datti, J. Wrana, S.O. Kelley, A.D.  Schimmer
     Blood, 2010, 116, 3593.

  72. "Programming the Detection Limits of Biosensors through Controlled Nanostructuring."  
     L. Soleymani, Z. Fang, E.H. Sargent, S.O. Kelley 
     Nature Nanotechnology, 2009, 4, 844.

  73. "Direct, Electronic MicroRNA Detection Reveals Expression Profiles in 30 Minutes."  
     H. Yang, A. Hui, G. Pampalakis, L. Soleymani, F.-F. Liu, E. H. Sargent, S.O. Kelley
     Angew. Chem. Intl. Ed., 2009, 48, 8461.

  74. "A General Phase-Transfer Protocol for Metal Ions and its Application in Nanocrystal Synthesis. " 
     J. Yang, E.H. Sargent, S.O. Kelley, J. Ying 
     Nature Materials, 2009, 4, 844.

  75. "Direct Profiling of Cancer Biomarkers in Tumour Tissue Using a Multiplexed Nanostructured Microelectrode Integrated Circuit. " 
     Z. Fang, L. Soleymani, G. Pampalakis, M. Yoshimoto, J.A. Squire, E. H. Sargent, S.O. Kelley
     ACS Nano, 2009, 3, 3207.

  76. "Nanostructuring of Patterned Microelectrodes to Enhance the Sensitivity of Electrochemical Nucleic Acids Detection. "  
     L. Soleymani, X. Sun, H. Yang, B.J. Taft, E. H. Sargent, S.O. Kelley 
     Angew. Chem. Intl. Ed., 2009, 48, 8457.

  77. "Recent Advances in the Biological and Medical Applications of Cell-Penetrating Peptides."
     S.B. Fonseca, M. Pereira, S.O. Kelley 
     Adv. Drug. Del. Rev., 2009, 61, 953.

  78. "One-step Synthesis of DNA-Programmed Semiconductor Nanocrystals."  
     N. Ma, E.H. Sargent, S.O. Kelley
     Nature Nanotechnology, 2009, 4, 121.

  79. "Direct Electrocatalytic mRNA Detection Using PNA-Nanowire Sensors."  
     Z. Fang & S.O. Kelley 
     Anal. Chem., 2009, 81, 612.

  80. "An Electrochemical Immunosensor Based on Antibody-Nanowire Conjugates."  
     G. Pampalakis & S.O. Kelley 
     The Analyst, 2009, 134, 447

  81. "Mitochondria-Penetrating Peptides: Sequence Effects and Model Cargo Transport."
     L. Yousif, K.M. Stewart, K.L. Horton, S.O. Kelley
     ChemBioChem, 2009, 10, 2081.

  82. "Engineered Apoptosis-Inducing Peptides with Enhanced Mitochondrial Localization and Potency."
     K.L. Horton, S.O. Kelley
     J. Med. Chem., 2009, 52, 3293.

  83. "Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications."
     L. Yousif, K.M. Stewart, and S.O. Kelley
     ChemBioChem, 2009, 10, 1939.

  84. "Potential Use of Cetrimonium Bromide as an Apoptosis-Promoting Anticancer Agent for Head and Neck Cancer.."
     E. Ito, K.W. Yip D. Katz, S.B. Fonseca, D.W. Hedley, S. Chow, G.W Xu, T.E. Wood, C. Bastianutto, A.D. Schimmer, S.O. Kelley, F.F. Liu
     Molecular Pharmacology, 2009, 76, 969.

  85. "Nanomaterials for Ultrasensitive Electrochemical Biosensing."
     H. Lord & S.O. Kelley
     J. Matl. Chem., 2009, 19, 3127.