All Publications Selected Publications

2019

“High-Throughput Genome-Wide Phenotypic Screening via Immunomagnetic Cell Sorting.”
B. Mair, P.M. Aldridge, R.S. Atwal, D. Philpott, M. Zhang, S.N. Masud, M. Labib, A.H.Y. Tong, E.H. Sargent, S. Angers, J. Moffat,* S.O. Kelley*
Nature Biomed. Eng. 2019, in press, doi: https://doi.org/10.1038/s41551-019-0454-8

“A Multiplexed, Electrochemical Interface for Gene Circuit-Based Sensors.”
P. Sadat Mousavi, S.J. Smith, J.B. Chen, M. Karlikow, A. Tinafar, W. Liu, D. Ma, A.A. Green, S.O. Kelley,* K. Pardee*
Nature Chemistry, 2019, in press.

“A New Era in Liquid Biopsy: From Genotype to Phenotype.” S.O. Kelley and K. Pantel,
Clinical Chemistry2019, in press.

"High-Performance Nucleic Acids Sensors for Liquid Biopsy Applications."
J. Das and S.O. Kelley
Angew. Chem. Intl. Ed. 2019, in press. doi:10.1002/anie.201905005. link

“Peptide-Functionalized Nanostructured Microarchitectures Enable Rapid Mechanotransductive Differentiation."
Z. Wang, L. Zhang, M. Labib, H. Chen, M. Wei, M. Poudineh, B.J. Green, B. Duong, J. Das, S. Ahmed, E.H. Sargent, S.O. Kelley,
ACS Applied Materials and Interfaces 2019, in press. doi: 10.1021/acsami.9b13694. link

“Potential-Responsive Surfaces for Dynamic Manipulation of Cell Adhesion, Release and Differentiation.”
L. Zhang, Z. Wang, J. Das, M. Labib, S. Ahmed, E.H. Sargent, S.O. Kelley,
Angew. Chem. Intl. Ed. 2019, 58, 14519-14523. link

“Peptide-Mediated Electrochemical Steric Hindrance Assay for One-Step Detection of HIV Antibodies.”
S.S. Mahshid, S. Mahshid, A. Vallée-Bélisle, S.O. Kelley.
Anal. Chem201991, 4943-4947. link

“Nanoparticle-Mediated Capture and Electrochemical Detection of Methicillin-Resistant Staphylococcus aureus.”
C.R. Nemr, S.J. Smith, W. Liu, A.H. Mepham, R.M. Mohamadi, M. Labib, S.O. Kelley.
Anal. Chem201991, 2847-2853. link

"Lattice Anchoring Stabilizes Solution-Processed Semiconductors."
M. Liu, Y. Chen, C.S. Tan, R. Quintero-Bermudez, A.H. Proppe, R. Munir, H. Tan, O. Voznyy, B. Scheffel, G. Walters, A.P.T. Kam, B. Sun, M.J. Choi, S. Hoogland, A. Amassian, S.O. Kelley, F.P. García de Arquer, E.H. Sargent.
Nature 2019570, 96-101. link

"Phenotypic Profiling of Circulating Tumor Cells in Metastatic Prostate Cancer Patients Using Nanoparticle-Mediated Ranking." B.J. Green, V. Nguyen, E. Atenafu, P. Weeber, B.T.V. Duong, P. Thiagalingam, M. Labib, R.M. Mohamadi, A.R. Hansen, A.M. Joshua, S.O. Kelley. 
Anal. Chem. 2019, 91, 9348-9355. link

Anchored Ligands Facilitate Efficient B-Site Doping in Metal Halide Perovskites.
Z. Yang, M. Wei, O. Voznyy, P. Todorovic, M. Liu, R. Quintero-Bermudez, P. Chen, J.Z. Fan, A.H. Proppe, L.N. Quan, G. Walters, H. Tan, J.W. Chang, U.S. Jeng, S.O. Kelley, E.H. Sargent.
J. Am. Chem. Soc. 2019, 141, 8296-8305. link

"Contactless Measurements of Photocarrier Transport Properties in Perovskite Single Crystals."
X. Gong, Z. Huang, R. Sabatini, C.S. Tan, G. Bappi, G. Walters, A. Proppe, M.I. Saidaminov, O. Voznyy, S.O. Kelley, E.H. Sargent.
Nature Commun201910, 1591. link

“Spectrally Resolved Ultrafast Exciton Transfer in Mixed Perovskite Quantum Wells.”
A.H. Proppe, M.H. Elkins, O. Voznyy, R.D. Pensack, F. Zapata, L.V. Besteiro, L.N. Quan, R. Quintero-Bermudez, P. Todorovic, S.O. Kelley, A.O. Govorov, S.K. Gray, I. Infante, E.H. Sargent, G.D. Scholes.
J. Phys. Chem. Lett201910, 419-426. link

“Combining Desmopressin and Docetaxel for the Treatment of Castration-Resistant Prostate Cancer in an Orthotopic Model.”
R. Bass, D. Roberto, D.Z. Wang, F.P. Cantu, R.M. Mohamadi, S.O. Kelley, L. Klotz, V. Venkateswaran.
Anticancer Res. 201939, 113-118. link

2018

"Single Cell mRNA Cytometry via Sequence-Specific Nanoparticle Clustering and Trapping."
M. Labib, R.M. Mohamadi, M. Poudineh, S.U. Ahmed, I. Ivanov, C.L. Huang, M. Moosavi, E.H. Sargent, S.O. Kelley.
Nature Chemistry201810, 489-495. link

“Prismatic Deflection of Live Tumor Cells and Cell Clusters.”
P.M. Aldridge, M. Mukhopadhyay, S.U. Ahmed, W. Zhou, E. Christinck, R. Makonnen, E.H. Sargent, S.O. Kelley.
ACS Nano2018, 12, 12692-12700. link.

“Three-Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction.”
M. Poudineh, Z. Wang, M. Labib, M. Ahmadi, L. Zhang, J. Das, S. Ahmed, S. Angers, S.O. Kelley.
Nano Lett. 2018.18,7188-7193. link 

“Single-Cell Tumbling Enables High-Resolution Size Profiling of Retinal Stem Cells.”
S. Gomis, M. Labib, B.L.K. Coles, D. van der Kooy, E.H. Sargent, S.O. Kelley.
ACS Appl Mater Interfaces. 2018, 10, 34811-24816. link

“Programmable Metal/Semiconductor Nanostructures for mRNA-Modulated Molecular Delivery.”
L. Zhang, S.R. Jean, X. Li, T. Sack, Z. Wang, S. Ahmed, G. Chan, J. Das, A. Zaragoza, E.H. Sargent, S.O. Kelley.
Nano Lett. 2018,18, 6222-6228. link

“Curvature-Mediated Surface Accessibility Enables Ultrasensitive Electrochemical Human Methyltransferase Analysis.” 
G. Wang, J. Das, S. Ahmed, C.R. Nemr, L. Zhang, M. Poudineh, E.H. Sargent, S.O. Kelley.
ACS Sens. 20183, 1765-1772. link

“Profiling Circulating Tumour Cells and Other Biomarkers of Invasive Cancers.”
M. Poudineh, E.H. Sargent, K. Pantel, S.O. Kelley
Nature Biomedical Engineering20182, 74-82. link

“Dynamic CTC Phenotypes in Metastatic Prostate Cancer Models Visualized Using Magnetic Ranking Cytometry.”
L. Kermanshah, M. Poudineh, S. Ahmed, L.N.M. Nguyen, S. Srikant, R. Makonnen, F.P. Cantu, M. Corrigan, S.O. Kelley
Lab on a Chip 201818, 2055-2064. link

"A Multifunctional Chemical Probe for Local Micropolarity and Microviscosity in Mitochondria."
A. Jiménez-Sánchez, E. Lei, S.O. Kelley
Angew. Chem. Intl. Ed. Engl. 201857, 8891-8895. link

"Combinatorial Probes for High-Throughput Electrochemical Analysis of Circulating Nucleic Acids."
J. Das, I. Ivanov, T.S. Safaei, S.O. Kelley
Angew. Chem. Intl. Ed. Engl. 201857, 3711-3716. link archive

"Pore Shape Defines Paths of Metastatic Cell Migration."
B.J. Green, M. Panagiotakoloulou, F. M. Pramotton, G. Stefopoulos, S. O. Kelley, D. Poulikakos, A. Ferrari
Nano Letters 2018, 18, 2140-2147. link

“A Fully-Integrated and Automated Testing Device for PCR-free Viral Nucleic Acid Detection in Whole Blood.”
W. Liu, J. Das, A.H. Mepham, C.R. Nemr, E.H. Sargent, S.O. Kelley
Lab on a Chip201818, 1928-1935. link

"Mitochondrial Tyrosyl-DNA Phosphodiesterase 2 and its TDP2S Short Isoform."
S.-Y. N. Huang, I. Dalla Rosa, S.A, Michaels, D.V. Tulumello, K. Agama, S. Khiati, S.R. Jean, S.A. Baechler, V.M. Factor, S. Varma, J. Murai, L.M.M. Jenkins, S.O. Kelley, Y. Pommier
EMBO Reports 201819, e42139. link 

"DNA Polymerase Theta Increases Mutation Rates in Mitochondrial DNA."
S. Wisnovsky, T. Sack, D. J. Pagliarini, R.R. Laposa, S.O. Kelley
ACS Chemical Biology 2018, 13, 900-908. link

“Picosecond Charge Transfer and Long Carrier Diffusion Lengths in Colloidal Quantum Dot Solids.”
A.H. Proppe, J. Xu, R.P. Sabatini, J.Z. Fan, B. Sun, S. Hoogland, S.O. Kelley, O. Voznyy, E.H. Sargent
Nano Lett. 2018,18, 7052-7059. lin

“Multibandgap quantum dot ensembles for solar-matched infrared energy harvesting.”
Sun B, Ouellette O, García de Arquer FP, Voznyy O, Kim Y, Wei M, Proppe AH, Saidaminov MI, Xu J, Liu M, Li P, Fan JZ, Jo JW, Tan H, Tan F, Hoogland S, Lu ZH, Kelley SO, Sargent EH.
Nature Commun. 20189, 4003. link

“Compositional and orientational control in metal halide perovskites of reduced dimensionality.”
Quintero-Bermudez R, Gold-Parker A, Proppe AH, Munir R, Yang Z, Kelley SO, Amassian A, Toney MF, Sargent EH.
Nature Mater. 2018,10, 900-907. lin

"Metal-Organic Framework Thin Films on High-Curvature Nanostructures Toward Tandem Electrocatalysis."
De Luna P, Liang W, Mallick A, Shekhah O, García de Arquer FP, Proppe AH, Todorović P, Kelley SO, Sargent EH, Eddaoudi M.
ACS Appl Mater Interfaces. 2018,10, 31225-31232. link

"Metal-Organic Frameworks Mediate Cu Coordination for Selective CO2 Electroreduction."
Nam DH, Bushuyev OS, Li J, De Luna P, Seifitokaldani A, Dinh CT, García de Arquer FP, Wang Y, Liang Z, Proppe AH, Tan CS, Todorović P, Shekhah O, Gabardo CM, Jo JW, Choi J, Choi MJ, Baek SW, Kim J, Sinton D, Kelley SO, Eddaoudi M, Sargent EH.
J. Am. Chem. Soc. 2018, 140, 11378-11386. link 

"2D Metal Oxyhalide-Derived Catalysts for Efficient CO2 Electroreduction."
García de Arquer FP, Bushuyev OS, De Luna P, Dinh CT, Seifitokaldani A, Saidaminov MI, Tan CS, Quan LN, Proppe A, Kibria MG, Kelley SO, Sinton D, Sargent EH.
Adv Mater. 2018, 30, e1802858. link

“Activated Electron-Transport Layers for Infrared Quantum Dot Optoelectronics.”
J. Choi, J.W. Jo, F.P.G. de Arquer, Y.B. Zhao, B. Sun, J. Kim, M.J. Choi, S.W. Baek, A.H. Proppe, A. Seifitokaldani, D.H. Nam, P. Li, O. Ouellette, Y. Kim, O. Voznyy, S. Hoogland, S.O. Kelley, Z.H. Lu, E. H. Sargent
Advanced Materials 2018, 30, 1801720. link 

“2D Matrix Engineering for Homogeneous Quantum Dot Coupling in Photovoltaic Solids.”
J. Xu, O. Voznyy, M. Liu, A.R. Kirmani, G. Walters, R. Munir, M. Abdelsamie, A.H. Proppe, A. Sarkar, F.P. García de Arquer, M. Wei, B. Sun, M. Liu, O. Ouellette, R. Quintero-Bermudez, J. Li, J. Fan, L. Quan, P. Todorovic, H. Tan, S. Hoogland, S.O. Kelley, M. Stefik, A. Amassian, E.H. Sargent.
Nature Nanotechnology. 2018, 13, 456-462. link

“Hydronium-Induced Switching between CO2 Electroreduction Pathways.”
A. Seifitokaldani, C.M. Gabardo, T. Burdyny, C.T. Dinh, J.P. Edwards, M.G. Kibria, O.S. Bushuyev, S.O. Kelley, D. Sinton, E.H. Sargent
J. Am. Chem. Soc. 2018140, 3833-3837. link

“Synthetic Control over Quantum Well Width Distribution and Carrier Migration in Low-Dimensional Perovskite Photovoltaics.”
A.H. Proppe, R. Quintero-Bermudez, H. Tan, O. Voznyy, S.O. Kelley, E.H. Sargent
J. Am. Chem. Soc. 2018, 140, 2890-2896. link

"Synthetic Control over Quantum Well Width Distribution and Carrier Migration in Low-Dimensional Perovskite Photovoltaics."
A.H. Proppe, R. Quintero-Bernudez, H. Tan, O. Voznyy, S.O. Kelley, E.H. Sargent
J. Am. Chem. Soc. 2018140, 2890-2896. link

“Electron-Phonon Interaction in Efficient Perovskite Blue Emitters.”
X. Gong, O. Voznyy, A. Jain, W. Liu, R. Sabatini, Z. Piontkowski, G. Walters, G. Bappi, S. Nokhrin, O. Bushuyev, M. Yuan, R. Comin, D. McCamant, S.O. Kelley, E. H. Sargent
Nature Materials. 201817, 550-556. link

"Catalyst Electro-redeposition Controls Morphology and Oxidation State for Selective Carbon Dioxide Reduction."
P. De Luna, R. Quintero-Bermudez, C. T. Dinh, M. B. Ross, O. S. Bushuyev, P. Todorovic, T. Regier, S. O. Kelley, P. Yang, E. H. Sargent
Nature Catalysis, 2018, 1, 103-110. link

2017

“Tracking the Dynamics of Circulating Tumor Cell Phenotypes Using Nanoparticle-Mediated Magnetic Ranking.” 
M. Poudineh, P.M. Aldridge, S. Ahmed, B.J. Green, L. Kermanshah, V. Nguyen, C. Tu, R.M. Mohamadi, R.K. Nam, A. Hansen, S.S. Sridhar, A. Finelli, N.E. Fleshner, A.M. Joshua,  E.H. Sargent,  S.O. Kelley 
Nature Nanotechnology201712, 274-282. link

“Delivery and Release of Small-Molecule Probes in Mitochondria Using Traceless Linkers.”
 E.K. Lei and S.O. Kelley,
 Journal of the American Chemical Society2017139, 9455-9458. link

"Biexciton Resonances Reveal Exciton Localization in Stacked Perovskite Quantum Wells."
 M.H. Elkins, R. Pensack, A.H. Proppe, O. Voznyy, L.N. Quan, S.O. Kelley, E.H. Sargent, G.D. Scholes
 Journal of Physical Chemistry Letters20178, 3895-3901. link

"Amplified Micromagnetic Field Gradients Enable High-Resolution Profiling of Rare Cell Subpopulations" 
 M. Poudineh, E.H. Sargent, and S.O. Kelley 
 ACS Appl. Mater. Interfaces, 20179, 25683−2569. link 

"Power-Free, Digital and Programmable Dispensing of Picoliter Droplets using a Digit Chip"
 A. Mepham, J. Besant, A. Weinstein, I. Burgess, E.H. Sargent, S.O. Kelley 
 Lab On A Chip, 201717, 1505-1514. link

"High-Curvature Nanostructuring Enhances Probe Display for Biomolecular Detection."
 P. De Luna, S.S. Mahshid, J. Das, B. Luan, E.H. Sargent, S.O. Kelley, R. Zhou
 Nano Letters201717, 1289-1295. link

"Chemistry-Driven Approaches to Ultrasensitive Nucleic Acid Detection."
 S.J. Smith, C.R. Nemr, S.O. Kelley
 Journal of the American Chemical Society2017139, 1020-1028. link

"Advancing Ultrasensitive Molecular and Cellular Analysis Methods to Speed and Simplify the Diagnosis of Disease."
 S.O. Kelley
 Accounts of Chemical Research201750, 503-507 ("Holy Grails in Chemistry" issue). link

"Profiling Functional and Biochemical Phenotypes of Circulating Tumor Cells Using a Two-Dimensional Sorting Device."
 M. Poudineh, M. Labib, S. Ahmed, L.N.M. Nguyen, L. Kermanshah, R.M. Mohamadi, E.H. Sargent, S.O. Kelley
 Angew. Chem. Intl. Ed.201756, 163-168. link

 “Enhancing the Potency of Nalidixic Acid toward a Bacterial DNA Gyrase with Conjugated Peptides.” 
 M. Ahmed & S.O. Kelley,
 ACS Chemical Biology, 2017, 12, 2563-2569. link

"Multifunctional Quantum Dot DNA Hydrogels."
 L. Zhang, S.R. Jean, S. Ahmed, P.M. Aldridge, X. Li, F. Fan, E.H. Sargent, S.O. Kelley
 Nature Communications2017, doi:10.1038/s41467-017-00298-w. link 

"What are Clinically-Relevant Levels of Cellular and Biomolecular Analytes?"
 S.O. Kelley
 ACS Sensors2017, 2, 193-197. link 

“Isolation of Phenotypically-Distinct Cancer Cells using Nanoparticle-Mediated Sorting.” 
 B.J. Green, L. Kermanshah, M. Labib, S.U. Ahmed, P.N. Silva, L. Mahmoudian, I.-H. Chang, R.M. Mohamadi, J.V. Rocheleau, S.O. Kelley, 
 ACS Applied Materials and Interfaces20179, 20435-20443. link

"Biomolecular Steric Hindrance Effects Are Enhanced on Nanostructured Microelectrodes."
S.S. Mahshid, A. Vallee-Belisle, S.O. Kelley,
Analytical Chemistry2017, 89, 9751-9757. link

“Steric Hindrance Assay for Secreted Factors in Stem Cell Culture.”  
 W. Zhou, S.S. Mahshid, W. Wang, A. Vallee-Belisle, P.W. Zandstra, E.H. Sargent, S.O. Kelley, 
 ACS Sensors20172, 495-500. link

“Electrochemical DNA-Based Immunoassay That Employs Steric Hindrance to Detect Small Molecules Directly in Whole Blood.” S.S. Mahshid, F. Ricci, S.O. Kelley, A. Vallee-Belisle,
 ACS Sensors20172, 718-723. link

“Bioassays: Universal Sensitivity Booster.” S.O. Kelley,
 Nature Biomedical Engineering20171, 88. link

“Broadband Epsilon-near-Zero Reflectors Enhance the Quantum Efficiency of Thin Solar Cells at Visible and Infrared Wavelengths.”  A.J. Labelle, M.  
 Bonifazi, Y. Tian, C. Wong,  S. Hoogland, G. Favraud, G. Walters, B. Sutherland, M. Liu, J. Li, X. Zhang, S.O. Kelley, E.H. Sargent, A. Fratalocchi,
 ACS Applied Materials and Interfaces, 20179, 5556-5565. link

“New Technologies for Rapid Bacterial Identification and Antibiotic Resistance Profiling.”
 S.O. Kelley
 SLAS Technology201722, 113-121. link

“Mixed Quantum Dot Solar Cells.”
Z. Yang, J. Z Fan, A.H. Proppe, F. P. García de Arquer, D. Rossouw, O. Voznyy, X. Lan, M. Liu, G. Walters, R. Quintero-Bermudez, B. Sun, S. Hoogland, S.O. Kelley, E. H. Sargent
Nature Communications2017, DOI: 10.1038/s41467-017-01362-1. link

2016

"Enhanced Electrocatalytic Carbon Dioxide Reduction via Field-Inducted Reagent Concentration."
M. Liu, Y. Pang, B. Zhang, P. De Luna, O. Voznyy, J. Xu, X. Zheng, C. T. Dinh, F. Fan, C. Cao, F. P. García de Arquer, T. S. Safaei, A. Mepham, A. Klinkova, E. Kumacheva, T. Filleter, D. Sinton,  S.O. Kelley and E.  H. Sargent  
Nature2016, 537, 382-386. link

"DNA Clutch Probes for Circulating Tumor DNA Analysis."
J. Das, I. Ivanov, E.H. Sargent, S.O. Kelley 
Journal of the American Chemical Society, 2016138, 11009-11016. link

"Mechanistic Control of the Growth of Three-Dimensional Gold Sensors."
S. Mahshid, A.H. Mepham, S.S. Mahshid, I.B. Burgess, T.S.Safaei, E.H. Sargent, S.O. Kelley 
Journal of Physical Chemistry C2016, 120, 21123-21132. link

“High-Density Nanosharp Microstructures Enable Efficient Carbon Dioxide Electroreduction.” 
T.S. Safaei, A. Mepham, X. Zheng, Y. Pang, C.-T. Dinh, D. Sinton, S.O. Kelley, E.H. Sargent, 
Nano Letters201611, 7224-7228. link

"Mitochondria-Targeted Doxorubicin: a New Therapeutic Strategy Against Doxorubicin-Resistant Osteosarcoma."  
I. Buondonno, E. Gazzano, S.R. Jean, V. Audrito, J. Kopecka, M. Fanelli, I. C. Salaroglio, C. Costamagna, I. Roato, E. Mungo, C. M. Hattinger, S. Deaglio, S.O. Kelley, M. Serra, C. Riganti, 
Molecular Cancer Therapeutics201615, 2640-2652. link

"Mitochondrial DNA Repair and Replication Proteins Revealed by Targeted Chemical Probes." 
S. Wisnovsky, S.R. Jean, S.O. Kelley
Nature Chemical Biology201612, 567-573. link

"Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell."
S. Wisnovsky, E.K. Lei, S.R. Jean, S.O. Kelley 
Cell Chemical Biology2016, 23, 917-927. link

"Aptamer and Antisense-Mediated Two-Dimensional Isolation of Specific Cancer Cell Subpopulations."
M. Labib, B. Green, R. Mohamadi, A. Mepham, S. Ahmed, L. Mahmoudian, I.-H. Chang, E.H. Sargent, S.O. Kelley
Journal of the American Chemical Society2016, 138, 2476-2479. link

"Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria."
S.R. Jean, M. Ahmed, E.K. Lai, S.P. Wisnovsky
Accounts of Chemical Research201649, 1893-1902. link

"Electrochemical Methods for the Analysis of Clinically-Relevant Biomolecules."
M. Labib, E.H. Sargent, S.O. Kelley
Chemical Reviews2016, 116, 9001-9090. link

"Image-Reversal Soft Lithography: Fabrication of Ultrasensitive Biomolecular Detectors."
T.S.S. Safaei, J. Das, S.S. Mahshid, P.M. Aldridge, E.H. Sargent, S.O. Kelley 
Advanced Healthcare Materials2016, 5, 893-899. link

“Beyond CTC Capture: Next-Generation Devices and Materials.”
B. Green, T. Saberi Safaei, A. Mepham, M. Labib, R.M. Mohamadi, S.O. Kelley 
Angew. Chem. Intl. Ed.2016, 55, 1252-1265. link

"Interrogating Circulating Microsomes and Exosomes Using Metal Nanoparticles." 
Y.-G. Zhou, R.M. Mohamadi, M. Poudineh, L. Kermanshah, S. Ahmed, T.S. Safaei, R.K. Nam, E.H. Sargent, S.O. Kelley 
Small201612, 727-732. link

2015

"Peptide Targeting of an Antibiotic Prodrug Towards Phagosome-Entrapped Mycobacteria." 
 M.P. Pereira, J. Shi, S.O. Kelley 
 ACS Infectious Disease20151, 586-592. link

"Mitochondrial Targeting of Doxorubicin Eliminates Nuclear Effects Associated with Cardiotoxicity." 
 S.R. Jean, D.V. Tulumello, C. Riganti, S.U. Liyanage, A.D. Schimmer, S.O. Kelley
 ACS Chemical Biology201510, 2007-2015. link

“An Electrochemical Clamp Assay for Direct, Rapid Analysis of Circulating Nucleic Acids in Serum.” 
 J. Das, I. Ivanov, E.H. Sargent, S.O. Kelley 
 Nature Chemistry20157, 569-575. link 

"Disease Detectors." 
 S.O. Kelley
 Scientific American2015313, 49-51. link

“Fractal Circuit Sensors Enable Rapid Quantification of Biomarkers for Donor Lung Assessment for Transplantation.” 
A.T. Sage, J.D. Besant, L. Mahmoudian, M. Poudineh, X. Bai, R. Zamel, M. Hsin, E.H. Sargent, M. Cypel, M. Liu, S. Keshavjee, S.O. Kelley
Science Advances20151, e1500417link (featured in C&E News)

"A Digital Microfluidic Device with Integrated Nanostructured Microelectrodes for Electrochemical Immunoassays." 
D.G. Rackus, M.D.M. Dryden, A. Zaragoza, J. Lamanna, B. Lam, S.O. Kelley, A.R. Wheeler 
Lab on a Chip201515, 3776-3784. link

"Using the Inherent Chemistry of the Endothelin-1 Peptide to Develop a Rapid Assay for Pre-transplant Donor Lung Assessment." A.T. Sage, X. Bai, M. Cypel, M. Liu, S. Keshavjee, S.O. Kelley
Analyst2015140, 8092-8096. link

“Sorting of Circulating Tumor Cells by Epithelial Antigen Expression during Disease Progression in an Animal Model.” 
N. Muhanna, A. Mepham, R. Mohamadi, H. Chan, T. Khan, M. Akens, J.D. Besant, J. Irish, S.O. Kelley
Nanomedicine: Nanotechnology, Biology, and Medicine201511, 1613-1616link

"In Situ Electrochemical ELISA for Specific Identification of Captured Cancer Cells." 
T. Saberi Safaei, R.M. Mohamadi, E.H. Sargent, S.O. Kelley 
ACS Appl. Mater. Interfaces2015, 7, 14165-14169. *Selected as an ACS Editors Choice Article link

"Sample-to-Answer Isolation and mRNA Profiling of Circulating Tumor Cells." 
R. M. Mohamadi, I. Ivanov, J. Stojcic, R.K. Nam, E.H. Sargent, S.O. Kelley 
Analytical Chemistry, 2015, 87, 6258–6264link

"Rapid Electrochemical Phenotypic Profiling of Antibiotic-Resistant Bacteria."  
J.D. Besant, E.H. Sargent, S.O. Kelley 
Lab on a Chip201515, 2799-2807. link

“Programmable Definition of Nanogap Electronic Devices with Self-Inhibited Reagent Depletion.” 
B. Lam, W. Zhou, E.H. Sargent, S.O. Kelley 
Nature Communications20156, 6940. link

“Ultrasensitive Visual Readout of Nucleic Acids using Electrocatalytic Fluid Displacement.” 
J.D. Besant, J. Das, I.B. Burgess, W. Liu, E.H. Sargent, S.O. Kelley 
Nature Communications20156, 6978. link

“Velocity Valleys Enable Efficient Capture and Spatial Sorting of Nanoparticle-Bound Cancer Cells.” 
J.D. Besant, R.M. Mohamadi, P. Aldridge, Y.Li, E.H. Sargent, S.O. Kelley 
Nanoscale20157, 6278-6285. link

"Nanoparticle-Mediated Binning and Profiling of Heterogeneous Circulating Tumor Cell Subpopulations." 
R.M. Mohamadi, I. Ivanov, J.D. Besant, A. Malvea, A. Mepham,  A.L. Allan, L.E. Lowes, R.K. Nam, E.H. Sargent, S.O. Kelley 
Angew. Chem. Intl. Ed.2015, 127, 141-145. link  (featured in Science, “Editor’s Choice”).

2014

“Advancing the Speed, Sensitivity and Accuracy of Biomolecular Detection with Multi-Length Scale Engineering.” 
S.O. Kelley, C.A. Mirkin, D.R. Walt, R.F. Ismagilov, M. Toner, E.H. Sargent, 
Nature Nanotechnology20149, 969-980. link

"Highly Specific Electrochemical Analysis of Cancer Cells using Multi-Nanoparticle Labeling." 
Y. Wan*, Y. Zhou*, M. Poudineh, T. Saberi Safaei, R.M. Mohamadi, E.H. Sargent, S.O. Kelley 
Angew. Chem. Intl. Ed.2014, 53, 13361-13365. link

"Effect of Microelectrode Structure on Electrocatalysis at Nucleic Acid-Modified Sensors." 
Y. Zhou, Y. Wan, A. Sage, M. Poudineh, S.O. Kelley
Langmuir2014, 30, 14322-14328. link

"Structural Modifications of Mitochondria-Targeted Chlorambucil Alter Cell Death Mechanism but Preserve MDR Evasion." 
S.R. Jean, M.P. Pereira, S.O. Kelley 
ACS. Mol. Pharm.20148, 2675-2682. link

"Ultrasensitive Electrochemical Biomolecular Detection using Nanostructured Microelectrodes." 
A.T. Sage, J.D. Besant, B. Lam, E.H. Sargent, S.O. Kelley, 
Acc. Chem. Res.201447, 2417-2425. link

“Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s.” 
G. Giulio, E.-K. Bang, G. Molinard, D. Tulumello, S. Ward, S.O. Kelley, A. Roux, N. Sakai, S. Matile
J. Am. Chem. Soc.2014136, 6069-6074. link

"Three-Dimensional, Sharp-Tipped Electrodes Concentrate Applied Fields to Enable Direct Electrical Release of Intact Biomarkers from Cells." 
M. Poudineh, R. Mohamedi, A. Sage, L. Mahmoudian, E.H. Sargent, S.O. Kelley
Lab on a Chip2014, 14, 1785-1790. link

"Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery." 
S.R. Jean, D.V. Tulumello, S.P. Wisnovsky, E.K. Lei, M.P. Pereira
ACS Chem. Biol.20149, 323-333. link

2013

"Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent." 
S.P. Wisnovsky, J.J. Wilson, R. J. Radford, M.P. Pereira, M. Chan, R. Laposa, S.J. Lippard, S.O. Kelley 
Chem. Biol.201320, 1323-1328. link

"Proximal Bacterial Lysis and Detection in Nanoliter Wells Using Electrochemistry." 
J.D. Besant, J. Das, E.H. Sargent, S.O. Kelley 
ACS Nano20137, 8183-8189. link

"Tuning the Intracellular Bacterial Targeting of Peptidic Vectors." 
E. Lei, M. P. Pereira, S.O. Kelley, 
Angew. Chem. Intl. Ed.201352, 9660-9663. link

"Solution-Based Circuits Enable Rapid and Multiplexed Pathogen Detection." 
B. Lam, R.D. Holmes, L. Live, A. Sage, E. H. Sargent, S.O. Kelley
Nature Comm.20134, 2001. link

"Tuning the Bacterial Detection Sensitivity of Nanostructured Microelectrodes." 
J. Das, S.O. Kelley 
Anal. Chem.201385, 7333-7338. link

"Targeted Delivery of Doxorubicin to Mitochondria." G. Chamberlain, D.V Tulumello, S.O. Kelley 
ACS Chem. Biol.20138, 1389-1395. link

"An Electrochemical ELISA Featuring Proximal Reagent Generation: Detection of HIV Antibodies in Clinical Samples." 
A. Bhimji, A. Zaragoza, L. Live, S.O. Kelley
Anal. Chem.201385, 6813-6819. link

"Optimized Templates for Bottom-Up Growth of High-Performance Integrated Biomolecular Detectors." 
 B. Lam, R.D. Holmes, J. Das, M. Poudineh, A. Sage, E.H. Sargent, S.O. Kelley
 Lab on a Chip201313, 2569-2575. link

"Re-directing an Alkylating Agent to Mitochondria Alters Drug Target and Cell Death Mechanism." 
 R. Mourtada, S. B. Fonseca, S.P. Wisnovsky, M.P. Pereira, X. Wang, R. Hurren, J. Parfitt, L. Larsen, R.A.J. Smith, M.P. Murphy, A.D. Schimmer, S.O. Kelley 
 PLOS One20138, e60253. link

"Rapid and Specific Electrochemical Detection of Prostate Cancer Cells Using an Aperture Sensor Array." 
M. Moscovici, A. Bhimji, S.O. Kelley 
Lab on a Chip201313, 940-946. link

"Chip-Based Nanostructured Sensors Enable Accurate Identification and Classification of Circulating Tumor Cells in Prostate Cancer Patient Blood Samples ." 
I. Ivanov, J. Stojcic, A. Stanimirovic, E. Sargent, R.K. Nam, S.O. Kelley 
Anal. Chem.201385, 398-403. link

"DNA-Based Programming of Quantum Dot Properties." 
K.B. Cederquist, S.O. Kelley 
WIREs: Nanomedicine and Nanobiotechnology20135, 86-96. link

2012

"An Ultrasensitve, Universal Detector Based on Neutralizer Displacement." 
J. Das, K.B. Cederquist, P. Lee, E.H. Sargent, S.O. Kelley 
Nature Chemistry20124, 642-648. link

"Polymerase Chain Reaction-Free, Sample-to-Answer Bacterial Detection in 30 Minutes with Integrated Cell Lysis." 
B. Lam, Z. Fang, E.H. Sargent, S.O. Kelley 
Anal. Chem.201284, 21-25. link

"Tuning the Activity of Mitochondria-Penetrating Peptides for Delivery or Disruption." 
K.L. Horton, M.P. Pereira, K.M. Stewart, S.B. Fonseca, S.O. Kelley 
ChemBioChem201213, 476-485. link

"Nanostructured Biomolecular Detectors: Pushing Performance at the Nanoscale." 
K.B. Cederquist, S.O. Kelley 
Curr. Opin. Chem. Biol.201216, 415. link

2011

"DNA-Based Programming of Quantum Dot Valency, Self-Assembly, and Luminescence" 
 G. Tikhomirov, S. Hoogland, P.E. Lee, A. Fischer, E.H. Sargent, S.O. Kelley 
 Nature Nanotechnology20116, 485. link

"Direct Genetic Analysis of Ten Cancer Cells: Tuning Molecular Probe Design for Efficient mRNA Capture" 
 E. Vasilyeva, Z. Fang, M. Minden, E.H. Sargent, S.O. Kelley 
 Angew. Chem. Intl. Ed.201150, 4137. link

"Maximizing the Therapeutic Window of an Antimicrobial Drug by Imparting Mitochondrial Sequestration in Human Cells " 
 M.P. Pereira, S.O. Kelley 
 J. Am. Chem. Soc.2011133, 3260. link

"Hierarchical Nanotextured Microelectrodes Overcome the Molecular Transport Barrier to Achieve Rapid, Direct Bacterial Detection"  
 L. Soleymani, Z. Fang, B. Lam, X. Bin, E. Vasilyeva, A. Ross, E.H. Sargent, S.O. Kelley
 ACS Nano20115, 3360. link

"Development of Novel Peptides for Mitochondrial Drug Delivery: Amino Acids Featuring Delocalized Lipophilic Cations" 
 K.M. Stewart, R. Mourtada, S.O. Kelley 
 Pharm. Res.201128, 2808. link

"Peptide-Chlorambucil Conjugates Combat Pgp-Dependent Drug Efflux" 
 S.B. Fonseca, S.O. Kelley 
 ACS Med. Chem. Lett.20112, 419. link

"Re-routing Chlorambucil to Mitochondria Enhances Potency and Combats Drug Resistance in Cancer Cells" 
 S.B. Fonseca, M.P. Pereira, R. Mourtada, M. Gronda, R. Hurren, M.D. Minden, A.D. Schimmer, S.O. Kelley 
 Chem. Biol.201118, 445. link

"Solvatochromic Reagents for Multicomponent Reactions and their Utility in the Development of Cell-Permeable Macrocyclic Peptide Vectors" 
 B.H.Rotstein, R. Mourtada, S.O. Kelley, A.K. Yudin 
 Chemistry201117, 12257. link

"Protein Detection Using Arrayed Microsensor Chips: Tuning Sensor Footprint to Achieve Ultrasensitive Readout of CA-125 in Serum and Whole Blood."  
 J.Das, S.O. Kelley
 Analytical Chemistry201183, 1167.

2010

“Nanostructuring of Sensors Determines the Hybridization of Biomolecular Capture.” 
 X. Bin, E.H. Sargent, S.O. Kelley
 Analytical Chemistry201082, 5928.

"Nucleic Acid-Passivated Nanocrystals: Biomolecular Templating of Form and Function."  
 N. Ma, G. Tikhomirov, S.O. Kelley
Accounts of Chemical Research201043, 173.

"The Antiparasitic Agent Ivermectin Induces Chloride-Dependent Membrane Hyperpolarization and Cell Death in Leukemia Cells."  
 S. Sharmeen, M. Skrtic, M.A Sukhai, R. Hurren, M. Gronda, X. Wang, S.B. Fonseca, H. Sun, M.D. Minden. R. Batey, A. Datti, J. Wrana, S.O. Kelley, A.D.  Schimmer
 Blood2010116, 3593.

2009

"Programming the Detection Limits of Biosensors through Controlled Nanostructuring."  
 L. Soleymani, Z. Fang, E.H. Sargent, S.O. Kelley 
 Nature Nanotechnology20094, 844.

"Direct, Electronic MicroRNA Detection Reveals Expression Profiles in 30 Minutes."  
 H. Yang, A. Hui, G. Pampalakis, L. Soleymani, F.-F. Liu, E. H. Sargent, S.O. Kelley
 Angew. Chem. Intl. Ed.200948, 8461.

"A General Phase-Transfer Protocol for Metal Ions and its Application in Nanocrystal Synthesis. "  
 J. Yang, E.H. Sargent, S.O. Kelley, J. Ying 
 Nature Materials20094, 844.

"Direct Profiling of Cancer Biomarkers in Tumour Tissue Using a Multiplexed Nanostructured Microelectrode Integrated Circuit. "  
 Z. Fang, L. Soleymani, G. Pampalakis, M. Yoshimoto, J.A. Squire, E. H. Sargent, S.O. Kelley
 ACS Nano20093, 3207.

"Nanostructuring of Patterned Microelectrodes to Enhance the Sensitivity of Electrochemical Nucleic Acids Detection. "  
 L. Soleymani, X. Sun, H. Yang, B.J. Taft, E. H. Sargent, S.O. Kelley 
 Angew. Chem. Intl. Ed.200948, 8457.

"Recent Advances in the Biological and Medical Applications of Cell-Penetrating Peptides." 
 S.B. Fonseca, M. Pereira, S.O. Kelley 
 Adv. Drug. Del. Rev., 200961, 953.

"One-step Synthesis of DNA-Programmed Semiconductor Nanocrystals."  
 N. Ma, E.H. Sargent, S.O. Kelley
 Nature Nanotechnology20094, 121.

"Direct Electrocatalytic mRNA Detection Using PNA-Nanowire Sensors."  
 Z. Fang & S.O. Kelley 
 Anal. Chem.200981, 612.

"An Electrochemical Immunosensor Based on Antibody-Nanowire Conjugates."  
 G. Pampalakis & S.O. Kelley 
 The Analyst2009134, 447

"Mitochondria-Penetrating Peptides: Sequence Effects and Model Cargo Transport." 
 L. Yousif, K.M. Stewart, K.L. Horton, S.O. Kelley
 ChemBioChem2009, 10, 2081.

"Engineered Apoptosis-Inducing Peptides with Enhanced Mitochondrial Localization and Potency." 
 K.L. Horton, S.O. Kelley
 J. Med. Chem.2009, 52, 3293.

"Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications." 
 L. Yousif, K.M. Stewart, and S.O. Kelley
 ChemBioChem200910, 1939.

"Potential Use of Cetrimonium Bromide as an Apoptosis-Promoting Anticancer Agent for Head and Neck Cancer.." 
 E. Ito, K.W. Yip D. Katz, S.B. Fonseca, D.W. Hedley, S. Chow, G.W Xu, T.E. Wood, C. Bastianutto, A.D. Schimmer, S.O. Kelley, F.F. Liu
 Molecular Pharmacology200976, 969.

"Nanomaterials for Ultrasensitive Electrochemical Biosensing." 
 H. Lord & S.O. Kelley
 J. Matl. Chem.200919, 3127. 

2008

"Measurement Science: the Engine of Chemical Biology.”
S.O. Kelley, D.R. Walt
Curr. Opin. Chem. Biol., 2008, 12, 473. link

"Cell-Permeable Peptides as Delivery Vehicles for Biology and Medicine." 
K.M. Stewart, K.L. Horton, S.O. Kelley 
Org. Biomol. Chem., 2008, 6, 2242. link

"Mitochondria-Penetrating Peptides."
K.L. Horton, K.M. Stewart, S.B. Fonseca, Q. Guo, S.O. Kelley
Chemistry & Biology2008, 15, 375. link

"A Comparison of Quality of Dispersion of Single Wall Carbon Nanotubes using Different Surfactants and Biomolecules."
R. Haggenmueller, s. Rahatekar, J. Fagen, J. Chun, M. Becker, T. Krauss, R. Naik, L. Carlson, J. Kadla, P. Trulove, D. Fox, Z. Fang, S.O. Kelley, J. Gilman*,
Langmuir2008, 24, 5070.link

"Biotemplated Nanostructures: Directed Assembly of Electronic and Optical Materials using NanoscaleComplementarity."
N. Ma, E.H. Sargent, S.O.Kelley
J. Mat. Chem.2008, 18, 954. link

see link for full publication listing