Chip for transplant markers appears in Science Advances, featured in C&E News, Scientific American

Fri, 28 Aug 2015

In an effort spearheaded by Ph.D. student Andrew Sage and involving extensive collaboration with lung transplant specialist Dr. Shaf Keshavjee, a new chip-based approach was developed to analyze donated lung tissue for transplant suitability.   Because of the risk of primary graft dysfunction (PGD), transplant surgeons must be conservative when deciding whether or not to transplant a doanted lung.  Increasing the supply of usuable lungs is an important goal given that patients die while waiting for a transplant, and it is estimated that 40% of the lungs that are declined for transplant are in fact usable. The chip-based approach that was reported in Science Advances described a 20 minute assay that was able to quantitate expression levels of a panel of markers that predict transplant outcome, providing a valuable tool that could assist transplant decision making and increase the pool lungs available for transplant.  This work and its impact was highlighted by C&E News, GenomeWeb, Scientific American and the University of Toronto.