Biotemplated Nanomaterials

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The worlds of biology and semiconductor engineering have traditionally been quite distinct. The spontaneous assembly of biological materials presents a stark contrast to the rational fabrication required for high performance semiconductors. The merger of these diverse materials represents a tremendous opportunity, given that biomolecules can organize into intricate, functionally sophisticated structures exactly the sort of precise, elegant control urgently needed to make the next generation of materials for computing, communications, energy, and the environment. We use biomolecular templates - particularly nucleic-acids based scaffolds - for the synthesis of semiconductor nanocrystals. We have demonstrated that rational programming of the size and luminescence spectra of colloidal quantum dot nanocrystals is possible through the choice of nucleotide ligands responsible for nanoparticle nucleation, growth, stabilization, and passivation. Moreover, we have shown that nucleic acid conformation can be used to modulate structures of nanocrystals, and that complex three-dimensional structures can be assembled. 

Featured publications:

Zhang, L.; Jean, S. R.; Li, X.; Sack, T.; Wang, Z.; Ahmed, S.; Chan, G.; Das, J.; Zaragoza, A.; Sargent, E. H.; et al. Programmable Metal/Semiconductor Nanostructures for MRNA-Modulated Molecular Delivery.
Nano Lett. 2018, 18 (10), 6222–6228. https://doi.org/10.1021/acs.nanolett.8b02263.

Zhang, L.; Jean, S. R.; Ahmed, S.; Aldridge, P. M.; Li, X.; Fan, F.; Sargent, E. H.; Kelley, S. O. Multifunctional Quantum Dot DNA Hydrogels.
Nature Commun. 2017, 8 (1), 381. https://doi.org/10.1038/s41467-017-00298-w.

Tikhomirov, G.; Hoogland, S.; Lee, P. E.; Fischer, A.; Sargent, E. H.; Kelley, S. O. DNA-Based Programming of Quantum Dot Valency, Self-Assembly and Luminescence.
Nature Nanotechnol. 2011, 6 (8), 485–490. https://doi.org/10.1038/nnano.2011.100.

Ma, N.; Sargent, E. H.; Kelley, S. O. One-Step DNA-Programmed Growth of Luminescent and Biofunctionalized Nanocrystals.
Nature Nanotechnol. 2009, 4 (2), 121–125. https://doi.org/10.1038/nnano.2008.373.

De Luna, P.; Quintero-Bermudez, R.; DInh, C. T.; Ross, M. B.; Bushuyev, O. S.; Todorović, P.; Regier, T.; Kelley, S. O.; Yang, P.; Sargent, E. H. Catalyst Electro-Redeposition Controls Morphology and Oxidation State for Selective Carbon Dioxide Reduction.
Nature Catal. 2018, 1 (2), 103–110. https://doi.org/10.1038/s41929-017-0018-9.

Liu, M.; Pang, Y.; Zhang, B.; De Luna, P.; Voznyy, O.; Xu, J.; Zheng, X.; Dinh, C. T.; Fan, F.; Cao, C.; et al. Enhanced Electrocatalytic CO2 Reduction via Field-Induced Reagent Concentration.
Nature 2016, 537 (7620), 382–386. https://doi.org/10.1038/nature19060.

Saberi Safaei, T.; Mepham, A.; Zheng, X.; Pang, Y.; Dinh, C. T.; Liu, M.; Sinton, D.; Kelley, S. O.; Sargent, E. H. High-Density Nanosharp Microstructures Enable Efficient CO2 Electroreduction.
Nano Lett. 2016, 16 (11), 7224–7228. https://doi.org/10.1021/acs.nanolett.6b03615.

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