Rare/single cell analysis


Our research group was one of the first to use nanostructured materials to develop high-sensitivity electrochemical sensors for biomolecular analytes. Over the last ten years, we have applied these sensors to a range of biological targets relevant to the diagnosis of cancer and infectious disease, and have applied them in other areas related to transplant and regenerative medicine.

Featured publications:

Aldridge, P. M.; Mukhopadhyay, M.; Ahmed, S. U.; Zhou, W.; Christinck, E.; Makonnen, R.; Sargent, E. H.; Kelley, S. O. Prismatic Deflection of Live Tumor Cells and Cell Clusters.
ACS Nano 2018, 12 (12), 12692–12700. https://doi.org/10.1021/acsnano.8b07616.

Labib, M.; Mohamadi, R. M.; Poudineh, M.; Ahmed, S. U.; Ivanov, I.; Huang, C.-L.; Moosavi, M.; Sargent, E. H.; Kelley, S. O. Single-Cell MRNA Cytometry via Sequence-Specific Nanoparticle Clustering and Trapping.
Nature Chemistry 2018, 10 (5), 489. https://doi.org/10.1038/s41557-018-0025-8.

Poudineh, M.; Aldridge, P. M.; Ahmed, S.; Green, B. J.; Kermanshah, L.; Nguyen, V.; Tu, C.; Mohamadi, R. M.; Nam, R. K.; Hansen, A.; et al. Tracking the Dynamics of Circulating Tumour Cell Phenotypes Using Nanoparticle-Mediated Magnetic Ranking.
Nat. Nanotechnology 2017, 12 (3), 274–281. https://doi.org/10.1038/nnano.2016.239.

Labib, M.; Green, B.; Mohamadi, R. M.; Mepham, A.; Ahmed, S. U.; Mahmoudian, L.; Chang, I. H.; Sargent, E. H.; Kelley, S. O. Aptamer and Antisense-Mediated Two-Dimensional Isolation of Specific Cancer Cell Subpopulations. 
J. Am. Chem. Soc.2016https://doi.org/10.1021/jacs.5b10939.

Mohamadi, R. M.; Besant, J. D.; Mepham, A.; Green, B.; Mahmoudian, L.; Gibbs, T.; Ivanov, I.; Malvea, A.; Stojcic, J.; Allan, A. L.; et al. Nanoparticle-Mediated Binning and Profiling of Heterogeneous Circulating Tumor Cell Subpopulations. Angew. Chem. Intl. Ed. 2015, 54 (1), 139–143. https://doi.org/10.1002/anie.201409376.